ASAP Collaborative Research Network (CRN)
Aligning Science Across Parkinson’s (ASAP) | Michael J. Fox Foundation
ASAP is a global research initiative changing the way science is typically done. By emphasizing collaboration, generation of research-enabling resources, and data sharing, ASAP is accelerating the pace of discovery and informing the path to a cure for Parkinson’s disease. ASAP is managed by the Coalition for Aligning Science and implemented in partnership with The Michael J. Fox Foundation for Parkinson’s Research.
Access a unique portfolio of cutting-edge resources designed to deepen our understanding of Parkinson's disease (PD), generated by the ASAP CRN, an international, multidisciplinary, and multi-institutional network of collaborating teams working to address high-priority research questions. Explore diverse datasets focused on critical knowledge gaps in PD Functional Genomics, Neuro-Immune Interactions, and Circuitry/Brain-Body Interactions.
This openly shared collection includes significant resources like:
The Harmonized Human Postmortem Brain Sequencing Collection (offering standardized transcriptomic data from hundreds of donors).
The developing ASAP Parkinson Cell Atlas in 5D (PD5D) molecular atlas resource.
Numerous specialized datasets from leading research teams addressing high-priority questions.
Leverage these resources - emerging from a network committed to open science - to accelerate your research, uncover novel mechanisms, and identify potential therapeutic targets for Parkinson's disease.
Datasets
ASAP CRN
Data Collection Time Frame
2024 - Present
Participants
448 (and growing)
Geographical Coverage
International
Usage Examples
- Investigating the function of PD-associated genes and pathways at a molecular and cellular level.
- Mapping PD genetic risk factors onto specific brain cell types and biological processes.
- Understanding the role of neuroinflammation, microglia, astrocytes, and peripheral immune interactions in PD development and progression.
- Analyzing disruptions in neuronal circuits and brain-body communication relevant to PD symptoms and pathology.
- Exploring cell-type-specific changes in the human PD brain using single-cell and spatial omics data from postmortem tissue.
- Creating comprehensive molecular datasets or the Parkinson's brain.
- Identifying and validating novel therapeutic targets emerging from fundamental research into disease mechanisms.
Data Modalities
Transcriptomics
- Single nucleus RNA Sequencing
- PolyA RNA Sequencing
- Bulk RNA Sequencing
Clinical Data
- Demographics
- Medical History
Biosamples
- Postmortem Brain Tissue
- Other Tissues / Cells
Pathology
- Clinical Pathology Data
Interested in accessing this data?