ASAP Collaborative Research Network (CRN)
Aligning Science Across Parkinson’s (ASAP) | Michael J. Fox Foundation
ASAP is a global research initiative changing the way science is typically done. By emphasizing collaboration, generation of research-enabling resources, and data sharing, ASAP is accelerating the pace of discovery and informing the path to a cure for Parkinson’s disease. ASAP is managed by the Coalition for Aligning Science and implemented in partnership with The Michael J. Fox Foundation for Parkinson’s Research.
Access a unique portfolio of cutting-edge resources designed to deepen our understanding of Parkinson's disease (PD), generated by the ASAP CRN, an international, multidisciplinary, and multi-institutional network of collaborating teams working to address high-priority research questions. Explore diverse datasets focused on critical knowledge gaps in PD Functional Genomics, Neuro-Immune Interactions, and Circuitry/Brain-Body Interactions
This openly shared collection includes significant resources like:
- The Harmonized Human Postmortem Brain Sequencing Collection (offering standardized transcriptomic data from hundreds of donors).
- The developing ASAP Parkinson Cell Atlas in 5D (PD5D) molecular atlas resource.
- Numerous specialized datasets from leading research teams addressing high-priority questions.
Leverage these resources - emerging from a network committed to open science - to accelerate your research, uncover novel mechanisms, and identify potential therapeutic targets for Parkinson's disease.
Datasets
ASAP CRN
Data Collection Time Frame
2024 - Present
Participants
448 (and growing)
Geographical Coverage
International
Usage Examples
- Investigating the function of PD-associated genes and pathways at a molecular and cellular level.
- Mapping PD genetic risk factors onto specific brain cell types and biological processes.
- Understanding the role of neuroinflammation, microglia, astrocytes, and peripheral immune interactions in PD development and progression.
- Analyzing disruptions in neuronal circuits and brain-body communication relevant to PD symptoms and pathology.
- Exploring cell-type-specific changes in the human PD brain using single-cell and spatial omics data from postmortem tissue.
- Creating comprehensive molecular datasets or the Parkinson's brain.
- Identifying and validating novel therapeutic targets emerging from fundamental research into disease mechanisms.
Data Modalities
Transcriptomics
- Single nucleus RNA Sequencing
- PolyA RNA Sequencing
- Bulk RNA Sequencing
Clinical Data
- Demographics
- Medical History
Biosamples
- Postmortem Brain Tissue
- Other Tissues / Cells
Pathology
- Clinical Pathology Data