ASAP Collaborative Research Network (CRN)

Aligning Science Across Parkinson’s (ASAP) | Michael J. Fox Foundation

ASAP is a global research initiative changing the way science is typically done. By emphasizing collaboration, generation of research-enabling resources, and data sharing, ASAP is accelerating the pace of discovery and informing the path to a cure for Parkinson’s disease. ASAP is managed by the Coalition for Aligning Science and implemented in partnership with The Michael J. Fox Foundation for Parkinson’s Research.

Access a unique portfolio of cutting-edge resources designed to deepen our understanding of Parkinson's disease (PD), generated by the ASAP CRN, an international, multidisciplinary, and multi-institutional network of collaborating teams working to address high-priority research questions. Explore diverse datasets focused on critical knowledge gaps in PD Functional Genomics, Neuro-Immune Interactions, and Circuitry/Brain-Body Interactions.

This openly shared collection includes significant resources like:

  • The Harmonized Human Postmortem Brain Sequencing Collection (offering standardized transcriptomic data from hundreds of donors). 

  • The developing ASAP Parkinson Cell Atlas in 5D (PD5D) molecular atlas resource.

  • Numerous specialized datasets from leading research teams addressing high-priority questions.

Leverage these resources - emerging from a network committed to open science - to accelerate your research, uncover novel mechanisms, and identify potential therapeutic targets for Parkinson's disease.

Partner datasets
ASAP Initiative
Michael J Fox Foundation
Parkinson's Disease
ASAP Collaborative Research Network
Michael J Fox Foundation

Datasets

ASAP CRN

Data Collection Time Frame

2024 - Present

Participants

448 (and growing)

Geographical Coverage

International

Usage Examples

  • Investigating the function of PD-associated genes and pathways at a molecular and cellular level.
  • Mapping PD genetic risk factors onto specific brain cell types and biological processes.
  • Understanding the role of neuroinflammation, microglia, astrocytes, and peripheral immune interactions in PD development and progression.
  • Analyzing disruptions in neuronal circuits and brain-body communication relevant to PD symptoms and pathology.
  • Exploring cell-type-specific changes in the human PD brain using single-cell and spatial omics data from postmortem tissue.
  • Creating comprehensive molecular datasets or the Parkinson's brain.
  • Identifying and validating novel therapeutic targets emerging from fundamental research into disease mechanisms.

Data Modalities

Transcriptomics

  • Single nucleus RNA Sequencing
  • PolyA RNA Sequencing
  • Bulk RNA Sequencing

Clinical Data

  • Demographics
  • Medical History

Biosamples

  • Postmortem Brain Tissue
  • Other Tissues / Cells

Pathology

  • Clinical Pathology Data

Interested in accessing this data?

 

Request Access